Weight loss associated with lung cancer

In this sense, the Quality of Life study group decided to create a combined assessment system that Weight loss associated with lung cancer a core questionnaire, which Weight loss associated with lung cancer evaluate issues common to different cancer sites and treatments, and various modules complementing the core questionnaire These modules include specific aspects of treatments or disease sites: breast, head and neck and Weight loss associated with lung cancer A second generation of the core questionnaire, the QLQ-C30, has been used in multiple psychometric and clinical studies This module was developed to assess the specific symptoms of lung cancer and its treatment that were not covered at all, or insufficiently, in the core questionnaire.

Members of these departments have been continuously participating in different projects of the EORTC Quality of Life study group since Besides, clinical studies with different tumours, in which Quality of Life has been one of the main outcome variables, have been carried out in both departments The aims of the present study are to assess the biographic and clinical data of a sample of lung cancer patients with un-resectable disease, to study their QoL at different points in the treatment process, to assess changes at these treatment points and to evaluate differences between groups based on stage of disease and treatment modalities.

We expected the quality of life of the patients who fill in the questionnaires in the different assessment Weight loss associated with lung cancer to be moderately high, and to find few differences between groups based on stage of the disease or treatment modality. We also expected some reductions in QoL during the treatment process that could improve in the follow-up period.

Materials and methods. An initial sample of consecutive un-resectable lung cancer patients was recruited. These patients started their treatment at the Oncology Department of the Hospital of Navarre between January and June Patients with a life expectancy lower than three months or with cognitive limitations were excluded.

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Cognitive function was assessed by a psychologist using selected questions from the Mini-Mental State Examination Both instruments have been validated for use in Spain In both instruments the scores range between 0 and In the module, higher scores represent higher levels of symptomatology.

The various scales and items of these instruments are considered as the main endpoints of this study. After obtaining verbal consent, patients filled Adelgazar 10 kilos these questionnaires at three different points: 1 at base-line on the first day of treatment; 2 the last day of the second chemotherapy cycle to study the effects of part of the treatment; 3 one month Weight loss associated with lung cancer the Weight loss associated with lung cancer of the treatment, at Weight loss associated with lung cancer follow-up visit, to study the cumulative effect of the treatment and the disease state.

We have established these assessment points in order to provide a view of Quality of Life during the whole treatment process and after considering factors such as patient fatigue and their interest in answering these instruments.

Each patient tried to complete the questionnaires themselves. If this was not possible but could be done with assistance, or if they preferred so, they were helped by a psychologist. Those cases in which the patient did not fill in the questionnaire were considered as missing data, and the reasons were recorded. Biographic and clinical data were taken from the clinical record. Performance status was assessed by the physician at the three time points with the Karnofsky scale 31as well as level of toxicity with selected items from the Common Toxicity Criteria 32 at the second and Weight loss associated with lung cancer measurement.

We have recorded the treatment modality proposed for patients who have completed just the first assessment and the actual treatment received in the rest of the sample radiotherapy, chemotherapy or combined.

The protocol treatment for the small cell lung cancer with limited disease group consisted of hyperfractionated radiotherapy cGy per session twice daily to a total dose of 45 Gy.

This cycle was repeated every 21 days until completing a total of four cycles. Cycles were administered each 21 days up to a total number of 4 to 6 depending Weight loss associated with lung cancer treatment tolerance and response.

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Radiotherapy was initiated between days 30 and 40 with hyperfractionated treatment of cGy twice daily to a total dose of cGy. This was repeated in the last week of radiotherapy, if the patient's general condition allowed it Four chemotherapy cycles were proposed.

These are the protocol treatments, but there could be some variation in the modality and duration of these treatments. Weight loss associated with lung cancer analysis.

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Weight loss associated with lung cancer

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Deterioration of general condition and weight loss; right hilar mass. Small-cell lung cancer with hepatic metastases. Deterioration of general condition, weight loss and general pain; right hilar mass.

Small-cell lung cancer with lung, mediastinal, bone, hepatic and suprarenal affectation. Affectation of the general condition and cough; left hilar mass.

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Small-cell undifferentiated carcinoma with hepatic and peritoneal metastases. Abdominal pain, affectation of the general condition and weight loss; right hilar mass. Small-cell lung carcinoma with pleural, hepatic and bone metastases. Subjective report of anorexia d. Abnormal biochemistry with one or more of the following: i.

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Patients Weight loss associated with lung cancer childbearing potential must use an effective method of avoiding pregnancy including oral, transdermal, or implanted contraceptives; an intrauterine device; male or female condoms; diaphragm or cervical cap with spermicide; or abstinence prior to randomisation and must agree to continue using such precautions until the end of the day safety follow up; 8.

Willing and able to comply with the protocol and to complete the study period; 9.

Bienvenido a EM-consulte, la referencia de los profesionales de la salud. El acceso al texto completo de Weight loss associated with lung cancer artículo requiere una suscripción o una Weight loss associated with lung cancer individual. We demonstrated that human cancer cachexia is associated with increased circulating concentrations of Activin A. Given the cachectic and anorectic effect of Activin A demonstrated in animal models, our observation suggests that Activin A might play a role in the development of human cancer cachexia. Indeed, circulating Activin A was correlated positively with weight loss and negatively with skeletal muscle density, two well-established prognosis factors in cancer patients. Our goal was to investigate the value of circulating Activin A as a marker of survival in cancer patients. Dietas depurativas para bajar de peso

Willing to forego other forms of experimental treatment during the study; Signed and dated informed consent, prior to receipt of any study medication or any study related procedures. ECOG performance status 0, 1 or 2 Pregnancy or lactation at screen or baseline visit; 2. Age greater than 80 or less than 25 at baseline visit; 4. Scheduled to Weight loss associated with lung cancer any new course of chemotherapy or to undergo a change in present chemotherapeutic regimen during the dose escalation phase of the study the first three weeks after randomisation ; 5.

Any surgical procedure within the past month or any planned surgical procedure; 6. Any mechanical obstruction of the alimentary canal; 7. Any history or evidence of intractable vomiting; 8. Adelgazar 72 kilos physical, medical, socioeconomic or other non-cancer related cause for simple starvation, muscle wasting or weight loss; Receiving enteral tube feeding or parenteral nutrition at screening or baseline visit; Select Date Range: to.

Select Rare Disease:. IMP with orphan designation in the indication. Orphan Designation Number:. Weight loss associated with lung cancer Status: Trials with results Trials without results.

Weight loss associated with lung cancer

Clear advanced search filters. Date on which this record was first entered in the EudraCT database:. A multicentre, randomised, double-blind, placebo-controlled, dose-finding phase II clinical study to evaluate the Weight loss associated with lung cancer of two different doses of MT administered over a sixteen week period in subjects with cachexia related to stage III and IV non-small cell lung cancer and colorectal cancer.

Title of the trial for lay people, in easily understood, i. A research study of a new drug MT for patients with weight loss and weakness cachexia related to lung or colorectal cancer. The IMP Weight loss associated with lung cancer been designated in this indication as an orphan drug in the Community.

Committee on Advanced therapies CAT has issued a classification for this product. Combination product that includes a device, but does not involve an Advanced Therapy.

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Advanced lung and colorectal cancer. Adult patients aged between 25 to 80 years of age and with a life expectancy of greater than 3 months as judged by the treating physician.

Aide-soignant e Anatomie Audioprothésiste Auxiliaire de puériculture. Cadre de santé Infirmier e Kinesitherapeuthe, Ostéopathe Orthophoniste. Orthoptiste Pédicure Podologue Psychomotricien.

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Nutrition clinique et métabolisme. Comprar el artículo Resumen Introduction and aim We demonstrated that human cancer cachexia is associated with increased circulating concentrations of Activin A. Results Among patients included Weight loss associated with lung cancer the study, survival data was available for patients. Conclusion In cancer patients, a high circulating concentration of Activin A was associated with a shorter overall survival.

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Archivos de Bronconeumologia http: www. Other types of articles such as reviews, Weight loss associated with lung cancer, special articles, clinical reports, and letters to the Editor are also published in the Journal. It is a monthly Journal that publishes a total of 12 issues, which contain these types of articles to different extents. All manuscripts are sent to peer-review and handled by the Editor or an Associate Editor from the team.

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The Journal is published both in Spanish and English. Therefore, the submission of manuscripts written in either Spanish or English is welcome. Translators working for the Journal are in charge of the corresponding translations.

See more Access to any published article, in either language, is possible through the Journal web page as well as from Pubmed, Science Direct, and other international databases. Furthermore, the Journal is also present in Twitter and Facebook. The Impact Factor measures the average number of citations received Weight loss associated with lung cancer a particular year by papers published in the journal during the two receding years.

CiteScore measures average citations received per document published. Read Weight loss associated with lung cancer. SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.

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SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. The CA Increased serum levels of CA The notably high CA In the time period, we treated 4 males, all with important smoking histories, non-small-cell lung cancer and CA Mean age was CA CYFRA This, together with high CA In the 4 cases, abdominal computed tomography CT ruled Weight loss associated with lung cancer pancreatic masses.

Meanwhile, neuron-specific enolase determined in 3 patients was clearly high, as was pro-gastrin-releasing peptide Pro GRPwith values that were times above normal. The poor survival in the Weight loss associated with lung cancer patients just 16 weeks on average reflected the advanced clinical state at presentation.

Tumor markers are substances that Weight loss associated with lung cancer produced or induced by either a tumor or by the surrounding tissues. Their main application resides in follow-up, in the evaluation of treatment efficacy and in prognosis.

Nevertheless, publications in the medical literature about the management of this entity do not recommend the systematic use of tumor markers due to their very limited efficacy, and they hardly even mention CA It is therefore plausible although immunohistochemistry techniques are not done that the origin of their increased level is the neoplastic bronchiolar epithelium, 7 regardless of the potential Adelgazar 15 kilos of the hepatic metastasis in all the reported cases.

It can thus be deduced that CA This consideration may be useful in order to properly interpret analytic and imaging results in this context. Carcinoma microcítico de pulmón y elevación del marcador tumoral CA Arch Bronconeumol. Archivos de Bronconeumología English Edition.

ISSN: Open Access Option. Previous article Next article.

Issue Pages October Lee este artículo en Español. Letter to the Editor. Download PDF. José María Prieto De Paula a ,?? Corresponding author. This item has received. Article information. Table 1. The clinical utility of CA Am J Gastroenterol, 85pp. Maestranzi, R. Przemioslo, H.

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Mitchell, R. Ann Clin Biochem, 35pp.

Measurements

Sohda, Y. Iwata, H. Shijo, Y.

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Egashira, K. Egashira, M. Increased expression of proliferating cell nuclear antigen in autoimmune hepatitis in a patient with raised serum concentration of CA J Clin Pathol, 51pp.

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Kausch, S. Krüger, S. Fetscher, A. Böhle, D. Elevation of CA in giant hydronephrosis induced by Weight loss associated with lung cancer renal calculus. Urology, 63pp. Rottenberg, B. Nisman, T. Extreme high levels of CA Isr Med Assoc J, 11pp. Nagami, T.

Nohara, M. Yamauchi, K. Yamada, A. A case of two patients with primary lung cancer secreting CA Nippon Geka Gakkai Zasshi, 89pp. López-Gómez, M. López-Ruz, J.

Weight loss associated with lung cancer

Elevación del marcador tumoral CA en un adenocarcinoma pulmonar. Rev Clin Esp,pp. Navarro Expósito, B. Prieto Ríos, M. Martín Angulo, M. Indicaciones de solicitud y valor de Weight loss associated with lung cancer marcadores tumorales. Medicine, 10pp. Molina, J. Auge, X. Filella, N. Viñolas, J.

Alicarte, J. Domingo, et al. Anticancer Res, 25pp.

Weight loss associated with lung cancer

Espinosa Arranz, J. Med Clin Barc96pp. Subscribe to our newsletter. Print Send to a friend Export reference Mendeley Statistics. Instructions for authors Submit an article Ethics in publishing.

Weight loss associated with lung cancer

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